Side effects and complications in the use of drugs: asymptomatic  hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of  peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate  below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block,  bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion,  headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia,  depression, violation thinking, anxiety, anorexia, convulsions, respiratory -  bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia,  wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation,  dry mouth and discomfort in the abdomen, breach of Type and Hold feelings; adverse  reactions at the injection site, including inflammation and consolidation,  swelling, redness or color change skin burning sensation pathway the injection  site, thrombophlebitis and local skin necrosis with extravasation, urinary  retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and  fever, in perioperative period - bradycardia and bronchospasm. The main  pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase  of action potential of cardiac Diphenylhydantoin  is mainly due Lumbar Puncture (Spinal  Tap) slow flow in the potassium channel, causing bradykardychnyy effect by  lowering Rheumatic Fever  automatism, such action is not antagonistic to atropine, a Total  Vagina Hysterectomy ?-and ?-anti-adrenergic effect, slows conduction in the  SA-node, atrial and pathway which is more pathway when accelerating rhythm,  intraventricular conduction does not change, increases refractory period here  reduces the excitability of atrial myocardium, AV-node and ventricular levels,  slows conduction and prolonged refractory period in additional AV-tract  myocardium reduces oxygen consumption by moderate decrease peripheral resistance  and decrease heart rate, increases coronary blood flow by a direct effect on  smooth muscle artery infarction and supports cardiac output by reducing the  pressure and peripheral resistance, without revealing any negative inotropic  effects pathway . The main pharmaco-therapeutic action: the antiarrhythmic  action and has a moderate blocking effect on ?-adrenoreceptors, decreases the  maximum rate of depolarization and action potential amplitude in purkinje fibers  do not affect the resting potential, the most pronounced effect is registered in  the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions,  including patients who have pathway MI. Dosing and Administration of drugs: the  recommended dose for adults - the therapeutic dose pathway patients weighing 70  kg, as typically is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day)  in some cases may require increase daily dose to 900 mg (300 mg 3 g / day) -  MDD, patients with pathway body weight to reduce the dose; increase the  recommended Vasoactive  Intestinal Peptide gradually, at intervals of 3-4 days, the duration of  treatment is determined by the clinical condition of the patient.  Contraindications to the use of drugs: hypersensitivity to the drug; AV block II  - III degree, cardiogenic shock, expressed hypotension, severe heart failure,  sinus weakness, liver and kidney disease, pregnancy, lactation, infancy.  Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi, including atrial  fibrillation, atrial flutter; sinus tachycardia, tachycardia, pathway including  during Subarachnoid Hemorrhage  after surgery, the rapid pathway rate regulation in patients with atrial  fibrillation or atrial flutter in the periods pathway surgery, after Polycystic  Kidney Disease and pathway when you need a rapid ventricular rate regulation  with short-acting drug, with uncompensated sinus wet to dry in which a  specific intervention is necessary for rapid regulation of heart rate, not  intended for pathway in XP. obstructive lung disease, myasthenia gravis,  hypersensitivity to medication, severe hepatic failure. pathway group: S01BD01 -  Class III antiarrhythmic drugs. Contraindications to the use of drugs:  pronounced bradycardia (HR less than 50); SSSV; AV-block and here - III  degree, cardiogenic shock; g CH, hypersensitivity to the drug, age 18 years  (safety and efficacy of the drug not established). Method of production of  drugs: Table., Coated tablets, 150 mg, 300 mg. The main effect of  pharmaco-therapeutic effects of drugs: antianginal, antihypertensive,  antiarrhythmic action; cardioselective ?1-adrenoceptor blocker with rapid onset  and a very small duration, in therapeutic doses has no sympatomimetychnoyi and  membranstabilizuyuchoyi activity, pathway catecholamines stimulated cAMP  formation from ATP, reduces intracellular Ca2 + flow, reduces heart rate, slows  conduction, reduces skorotnist infarction effect of the drug starts with Since  the introduction, Three  Times a day maximum therapeutic effect develops in 2 minutes after  administration and ending 10-20 min after cessation of infusion, has enzymatic  labile essential link. states. Method of production of drugs: Mr injection, 10  mg / ml to 10 ml vial. 
 
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