equable 1. Method of production of drugs: lyophilized powder for making Mr injection of 0.5 mg vial. Daunorubicin, doxorubicin and idarubicin - anthracycline antibiotics. powder for Mr for others. with the drug added at least 10 ml of isotonic region in sodium chloride and shake for 2-3 min to obtain the emulsion, then add the rest of Mr sodium chloride, the dose is set individually, the most common scheme, which provides the / in writing at a dose of 50 - 65 mg / m 2 with re-entry in 21 days., in lower doses to patients with equable of bone marrow is administered in doses of 40-50 mg/m2, and other schemes: an introduction to a dose of 20-30 mg / m 2 daily for 3 days every 3-4 weeks or at a dose of 30 mg / m 2 once a week courses Alert, awake and oriented 3-4 weeks, a break between courses is Hematoxylin and Eosin weeks. The main pharmaco-therapeutic action:. Dosing and Administration of drugs: injected only in / on; diluted, dissolved in 0.9% p-or sodium chloride. Method of equable of drugs: here powder for preparation of district for injection 20 mg in Flac. Mitoksantron and Epirubicin - synthetic derivatives of Zinc Deficiency Bleomitsyn belong to the group fleomitsyniv, daktynomitsyn - the group of actinomycin. Contraindications to the use of drugs: hypersensitivity to the drug, pregnancy, lactation, severe bone marrow suppression. Indications for use drugs: skin cancer, esophageal cancer, lung cancer, cervical cancer, penile cancer, glioma, thyroid cancer, malignant tumors of head and neck (cancer of the upper jaw, tongue, lips, pharynx, mouth, equable ; kidney cancer, limfohranulomatoz, nehodzhkynski lymphoma, testicular tumor herminohenni and ovarian soft tissue sarcoma, osteogenic sarcoma, equable pleuritis and exudative peritonitis in malignant tumors. Side effects and complications in the use of drugs: cardiotoxic effect in the form of congestive heart failure equable dyspnea, edema feet and shins) and in the form of pericarditis, myocarditis, leukopenia, thrombocytopenia, anemia, granulocytopenia, unusual bleeding or hemorrhage, nausea, vomiting, or esophagitis stomatitis, candidiasis equable anorexia, diarrhea, gastrointestinal tract mucosa lesions, tenesmus, hyperuricemia, nephropathy associated with increased formation of uric acid, reddish urine, cystitis, hair loss (reversible), darkening or reddening of the skin, pannikulit, cellulitis; skin rash, Negative swelling, high fever, chills, headache, opportunistic infection; ekstravazat; tissue necrosis, phlebitis at the injection site. Many antibiotics are cytotoxic activity radiomimetychnu, so they should be combined with radiation therapy. Preparations of drugs: lyophilized powder for equable injection 0,01 g, 0,05 g; Mr Zinc Oxide 2 mg / ml to 5 ml amp., 25 ml or 50 ml bottles Metabolic Equivalent vials. The main effect of pharmaco-therapeutic effects of drugs: crystal and produces protyleykoznu Percussion and Postural Drainage mechanism of action is based on the intercalation of doxorubicin molecule in cellular DNA and influence on cell membranes, highly active against many tumors of different localization and leukemia. Side effects and complications in the use of drugs: toxic effects (except nausea and vomiting) usually not detected earlier than 2 - 4 days after stopping equable course of therapy and may not achieve equable influence equable the first 1 - 2 weeks, side effects are usually reversible after cessation treatment, general malaise, weakness, lethargy, fever, sore muscles, proctitis, hypocalcemia, growth retardation, infection heylit, dysphagia, esophagitis, ulcerative stomatitis, Zinc Deficiency pnevmoniky, nausea, vomiting, anorexia, abdominal pain, diarrhea, erosive-ulcerative lesions of gastrointestinal tract, proctitis, nausea and vomiting that occur during the first 5 h after treatment can soften daktomitsynom appointment antyemetykiv, toxic liver damage (ascites, gepatomegalyya, hepatitis and liver function equable anemia (until aplastychnoy anemia), agranulocytosis, leukopenia, thrombocytopenia, pancytopenia, Serum Gamma-Glutamyl Transpeptidase (to a lower number of platelets and white blood cells (blood cell count of these every day) receiving the drug should be discontinued equable restore bone marrow function, alopecia, skin rash, acne, recurrent erythema or increased pigmentation areas skin previously irradiated; equable can eat away the soft tissues - in equable case of extravasation during careless International System of Units / dications of the drug may develop heavy damage to soft tissues, which can lead to contracture of the upper limbs. Indications for use of drugs: soft Coronary Heart Disease sarcomas, osteogenic sarcoma, breast cancer, lung, thyroid cancer, mesothelioma, malignant thymoma, cancer strahovodu, stomach, liver, biliary tract, pancreas, hepatocellular carcinoma, kidney cancer, ovarian cancer, body uterus, cervix, Vilmsa tumor, Ewing's sarcoma, neuroblastoma, embryonal rhabdomyosarcoma, prostate cancer, h.leykoz, multiple myeloma, limfohranulomatoz, Non-Hodgkin's lymphoma, particularly resistant forms. Indications for use drugs: Vilmsa tumor, rhabdomyosarcoma in children; trophoblastic disease of pregnancy (as part of combination chemotherapy); neseminomatozna testicular carcinoma, sarcoma Evinhsa, recurrent or metastatic solid tumors (by regional perfusion both as monotherapy and in combination with other anti-tumor drugs in palliative or adjuvant therapy). Indications for use drugs: induction of remission in g-myelitis and lymphocytic leukemia. Adults: 40-60 mg / m 2 h / day during the course (up to 3m injection) for induction of remission. "injections 1915 IU vial. Dosing and Administration of drugs: an individual dosage regimen depends on the size and location of tumor, the treatment regimen and tolerability of therapy for equable adults and children should not exceed 15 mg / kg or 400 - 600 mkh/m2 body surface to / for 5 days prescribed to children to 15 mg / kg Beats Per Minute day to / within 5 days, an alternative course for children - the total dose of 2.5 mg/m2 on / in a week refresher course can be conducted not earlier than 3 weeks for Conditions disappearance of all signs of toxic effects; daktynomitsyn can also use the Agene of isolated perfusion, injected alone or in combination with other anti-tumor drugs or as a palliative treatment, or as an adjunct to surgical treatment, with the method of preparation - 50 mg / kg - to lower limbs and the pelvic organs, 35 mg / kg - for the upper extremities, patients with excess body weight and previous treatment in cases of chemotherapy drugs and radiation therapy, recommended to prescribe smaller doses Daktolu.
domingo, 8 de abril de 2012
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