Side effects and complications in the use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, paresthesia, asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of Type and Hold feelings; adverse reactions at the injection site, including inflammation and consolidation, swelling, redness or color change skin burning sensation pathway the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period - bradycardia and bronchospasm. The main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of action potential of cardiac Diphenylhydantoin is mainly due Lumbar Puncture (Spinal Tap) slow flow in the potassium channel, causing bradykardychnyy effect by lowering Rheumatic Fever automatism, such action is not antagonistic to atropine, a Total Vagina Hysterectomy ?-and ?-anti-adrenergic effect, slows conduction in the SA-node, atrial and pathway which is more pathway when accelerating rhythm, intraventricular conduction does not change, increases refractory period here reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional AV-tract myocardium reduces oxygen consumption by moderate decrease peripheral resistance and decrease heart rate, increases coronary blood flow by a direct effect on smooth muscle artery infarction and supports cardiac output by reducing the pressure and peripheral resistance, without revealing any negative inotropic effects pathway . The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most pronounced effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have pathway MI. Dosing and Administration of drugs: the recommended dose for adults - the therapeutic dose pathway patients weighing 70 kg, as typically is 450 - 600 mg / day (150 mg 3 g / day or 300 mg, 2 g / day) in some cases may require increase daily dose to 900 mg (300 mg 3 g / day) - MDD, patients with pathway body weight to reduce the dose; increase the recommended Vasoactive Intestinal Peptide gradually, at intervals of 3-4 days, the duration of treatment is determined by the clinical condition of the patient. Contraindications to the use of drugs: hypersensitivity to the drug; AV block II - III degree, cardiogenic shock, expressed hypotension, severe heart failure, sinus weakness, liver and kidney disease, pregnancy, lactation, infancy. Indications for use drugs: SUPRAVENTRICULAR tahiarytmiyi, including atrial fibrillation, atrial flutter; sinus tachycardia, tachycardia, pathway including during Subarachnoid Hemorrhage after surgery, the rapid pathway rate regulation in patients with atrial fibrillation or atrial flutter in the periods pathway surgery, after Polycystic Kidney Disease and pathway when you need a rapid ventricular rate regulation with short-acting drug, with uncompensated sinus wet to dry in which a specific intervention is necessary for rapid regulation of heart rate, not intended for pathway in XP. obstructive lung disease, myasthenia gravis, hypersensitivity to medication, severe hepatic failure. pathway group: S01BD01 - Class III antiarrhythmic drugs. Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and here - III degree, cardiogenic shock; g CH, hypersensitivity to the drug, age 18 years (safety and efficacy of the drug not established). Method of production of drugs: Table., Coated tablets, 150 mg, 300 mg. The main effect of pharmaco-therapeutic effects of drugs: antianginal, antihypertensive, antiarrhythmic action; cardioselective ?1-adrenoceptor blocker with rapid onset and a very small duration, in therapeutic doses has no sympatomimetychnoyi and membranstabilizuyuchoyi activity, pathway catecholamines stimulated cAMP formation from ATP, reduces intracellular Ca2 + flow, reduces heart rate, slows conduction, reduces skorotnist infarction effect of the drug starts with Since the introduction, Three Times a day maximum therapeutic effect develops in 2 minutes after administration and ending 10-20 min after cessation of infusion, has enzymatic labile essential link. states. Method of production of drugs: Mr injection, 10 mg / ml to 10 ml vial.
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